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Khothatso le Ts'ebeliso ea Phofo e Omisitsoeng ea Phofo e Omisitsoeng ea Dragon Snake 'Marakang oa Lefatše
Lilemong tsa morao tjena, meriana ea biochemical hemostatic haholo-holo e entsoeng ka enzyme ea mahloko a noha e 'nile ea sebelisoa ka ho fetisisa tleliniking' me e se e le eona e ka sehloohong ea nts'etsopele ea meriana ea phekolo.
Lithethefatsi tsa hemostatic, tse tsejoang hape ka hore ke litlhare tsa procoagulant, hangata ke lithethefatsi tse nang le karolo ts'ebetsong ea ho kopanya mali, ho kenyelletsa le ho potlakisa ho putlama ha mali kapa ho fokotsa ho kenella ha capillary ho emisa ho tsoa mali.Ke tsona tse ka sehloohong le tsa bohlokoa haholo tsa kalafo bakeng sa kalafo ea mafu a hemorrhagic kapa boemo ba mali.
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Liphello tse Supileng tsa Antithrombotic li ile tsa sebelisoa
Ho na le mefuta e 'meli ea liprotheine mahlokong a noha, e 'ngoe ea eona e otlolohile.Ensaeme e qhaqhang fibrin (protolysin) e bitsoa fibrin (protolysin) enzyme (E khuts'oanyane bakeng sa plasminase,fi b ri no L yt I cenz YM E, FLE).Ntle le ho nyenyefatsa fibrin le fibrinogen, Ha ho ts'ebetso ea plasminogen 'meleng oa motho, ha ho na hydrolysis ea lintlha tse ling tsa coagulation Le lera la platelet, le na le phello e hlakileng ea antithrombotic.E 'ngoe ke ka khatello ea Prothrombin e kenngoa tšebetsong ho liehisa ts'ebetso ea coagulation mme ha e na ts'ebetso ea enzyme.
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Tšebeliso ea Chefo ea Noha ho Emisa ho Tsoa ha Mali le ho Thibela ho Thibela mali
Ka 1981, defibrase e ntšitsoeng le ho ntlafatsoa ke Kunming Institute of Zoology, Yunnan, Chaena, ho tloha chefong ea noha ea pentameter ea Chaena e ile ea feta tekolo ea tekheniki 'me ea sebelisoa ho phekola linyeoe tse 333 tsa vascular thrombosis, ho akarelletsa le linyeoe tse 242 tsa cerebral thrombosis. sekhahla se sebetsang sa 86.4%.Agkistrodon agkistrodon acidase, e entsoeng ke China Medical University le Shenyang Pharmaceutical College, e sebelisitsoe ho phekola li-vascular occlusives ka liphello tse khotsofatsang tsa kliniki.Snake Venom Laboratory ea China Medical University ntshetswa pele noha mahloko antacid enzyme, e ka fokotsa lipids mali, dilate methapo ea mali, fokotsa diteng tsa thrombin maling, eketsa prostacyclin, le phomotse mesifa boreleli ea methapo ea mali.Ke setlolo se setle sa anticoagulant thrombolytic.
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Ntša Bohloko ba Noha ho Phofo e Omisitsoeng ea Chefo ea Noha
1. Motsoako oa peptide ea chefo ea noha e nang le phofshoana e omisitsoeng ea chefo ea noha ke ea ts'ebeliso ea bongaka le tlhokomelo ea bophelo bo botle, e ka matlafatsang ts'ebetso ea ho lokisa mokoallo le ho liehisa ho hlaha ha masoba.Eketsa ho boloka metsi a letlalo, etsa hore letlalo le tiee le ho feta
2. Lokisa letlalo, thusa ho fifala le ho ntlafatsa mela e metle, ho notlela metsi hantle le ho nosetsa, ho hloekisa li-pores, ho fepa letlalo le ho etsa hore letlalo le be boreleli le ho khanya.
3. Motsoako o bonolo oa letlalo, o kenang botebong ba letlalo, o monyeha habonolo, o kenya liseleng tšebetsong, mats'ope a boreleli, o eketsa elasticity ea letlalo.
4. Fade wrinkles le tighten, lokisa letlalo senyehileng le tighten
Letlalo, fade mela e metle, matlafatsa mokoallo oa letlalo, imolla letlalo le omeletseng le le pshatlehang
Thusa ho nchafatsa letlalo, ho lokisa letlalo, ho fifala le ho ntlafatsa mela e metle, ho notlela metsi hantle le ho nosetsa, ho hloekisa li-pores, ho fepa letlalo, ho etsa hore letlalo le be boreleli le ho khanya. -
Bohloko ba Noha bo Tsoang ho Agkistrodon (Noha ea mehato e mehlano) e Lokela ho Phekoa ka Serum ea Antihematic.
Ho ile ha etsoa liteko tse peli tsa kliniki, teko e laoloang ke placebo le teko e laoloang ka mokhoa o nepahetseng.Maqeba ’ohle a ne a tsoa mali ka ho seha lebota la mpa ka ho buuoa ka mpeng.Li-index tsa mantlha tsa kalafo e ne e le tahlehelo ea mali, nako ea hemostasis le tahlehelo ea mali sebakeng se le seng.Li-placebo tse sa reroang litekong tsa kliniki maemong a 180 a batho: karolo ea lintlha tse lekanang le placebo, 2 u le 3 u lihlopha tse tharo, pele ho ts'ebetso metsotso e 15-20 lethal dose e le 'ngoe ea methapo, liphetho li fana ka maikutlo a hore litekanyetso tsena tse peli nakong ea ho tsoa mali, nako ea ho tsoa mali. tahlehelo ea mali ka index ea sebaka sa yuniti e ne e phahametse placebo, empa ha ho kamano ea karabelo ea mahloriso lipakeng tsa lihlopha tse peli.Tekong e ntle ea taolo, ho ne ho e-na le bakuli ba 324 sehlopheng sa liteko le bakuli ba 108 sehlopheng sa taolo, 'me tekanyo e le' ngoe ea 2U e ile ea fuoa sehlopha sa liteko 15-20 metsotso pele ho buuoa ka ente e le 'ngoe ea methapo.Ha ho maikutlo a mabe a ileng a bonoa litekong tse ka holimo.
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Tšebeliso ea Chefo ea Noha e khahlanong le mofetše
Lintho tse tala Phofo e ommeng ea chefo ea noha e hlahisoang ke k'hamphani ea rona e entsoe ka chefo e bokeletsoeng ea agkistrodon.
Phofo e omisitsoeng ea chefo ea noha e sebelisoa haholo meriana, sesole, botle le masimo a mang.Phofo e omisitsoeng ea chefo ea noha e na le mefuta e mengata ea ts'ebeliso le tebello e pharaletseng ea nts'etsopele. -
Analgesia ea Phofo e Omisitsoeng e Bohloko ba Noha
Tšebeliso ea chefo ea noha ho agkistrodon (noha ea mehato e mehlano): analgesia
Chefo ea noha e na le mesebetsi ea ho leleka moea le ho tlosa mongobo, anticoagulation le antithrombus, ho tlosa fibrinogen, ho fokotsa viscosity ea mali, ho fokotsa methapo ea mali, ho ntlafatsa microcirculation le ho theola lipids tsa mali.Bohloko ba agkistrodon agkistrodon bo na le boleng bo phahameng ba meriana, bo nang le likarolo tsa pharmacological tse khothalletsang ho coagulation, fibrinolysis, anti-cancer le analgesia.Mesebetsi ea mantlha ke:
1. Analgesia.
2. Khatello e tlaase ea mali.
3. Hemostasis le anticoagulation.
4. phello e khahlanong le mofetše.
5. phekolo ea thrombosis ea boko le vasculitis.
6. Phekola liso tsa ka mpeng le duodenal.
7. ke serum e thibelang mali.
8. Ho lemalla sesole le lithethefatsi -
Phofo e Omisitsoeng ea Chefo ea Noha Lisebelisoa tse ling
Agkistrodon agkistrodon e ntša chefo e ngata, 'me li-enzyme tse sebetsang li ruile, ke mofuta oa Liphuputso tsa morao-rao li lekanyelitsoe feela ho thrombin - joalo ka lipatlisiso Ho phaella moo, liphello tsa antitumor li boetse li tlalehiloe, ha lithuto tse ling tsa fisioloji kapa tsa pharmacological li bapisoa le Hanyenyane;Pele ho tsohle, a.agkistrodon e 'nile ea sebelisoa bakeng sa moea le dehumidification ka nako e telele Phello ea meriana ea moriana ona e ntse e lokela ho ithutoa.Taba ea bobeli, chefo ea noha e sebelisoa 'marakeng oa hajoale.
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Bohloko ba Noha bo na le Taba ea Kopo ea Botle ba Bongaka
Teko e sa khaotseng ea nako e na le liphello tse ngata, ’me ha re ntse re hōla, kaofela re ba liphofu.Ha letlalo la rona le khaotsa ho ikatisa, re oela ho sotleheng, mela e metle le masoebe.Seamax Cell regeneration Complex e nang le liminerale tsa Leoatle le Shoeleng e fana ka tharollo ea botle e lebisitsoeng ho sebelisa mekhoa e tsoetseng pele ea mahlale.
Mokhoa ona o ka qala ts'ebetso ea nchafatso ea lisele, oa qala nchafatso ea lisele tsa letlalo le ho hlahisa letlalo le phetseng hantle.Li-peptide tse bululetsoeng ke chefo ea noha li shebisisa tšebetso ea neuromuscular ho thibela li-receptor tsa mesifa tse sosobanang letlalo le ho baka masoebe.
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Tšebeliso ea ente ea chefo ea noha ea hemagglutinin
Bohloko ba noha hemagglutinin, bo nang le thrombin le thrombin, bo 'nile ba sebelisoa haholo ho phekola ho haella ha mali lilemong tse leshome tse sa tsoa feta.Thrombin e ka khothalletsa platelet aggregation sebakeng sa mali a tsoang mali, ea khothalletsa ho senyeha ha fibrinogen, ea hlahisa fibrin monomer, 'me e ntan'o etsa polymerize ho insoluble fibrin, e khothalletsa thrombosis sebakeng sa mali;Thrombin e kenya tšebetsong prothrombin mme e potlakisa tlhahiso ea thrombin, ka hona e nolofatsa ts'ebetso ea ho koala.
