[Abstract] Sepheo: Ho bona phello ea karolo ea I ea anti-tumor ea Agkistrodon acutus venom (AAVC-1) mosebetsing oa ho falla ha lisele tsa "umbilical vein endothelial cells" (HUVECs), le ho hlahloba mokhoa o ka khonehang oa AAVC - Ⅰ inhibiting. angiogenesis.Mekhoa: Li-HUVEC li ne li hloekisitsoe ka har'a vitro 'me li phekoloa ka AAVC - Ⅰ (0, 20, 40, 80 μ G / ml) lisele tse tšoaroang li ne li kenngoa ka 24 h.Teko ea mohatla le tlhahlobo ea kamore ea chemotactic li sebelisitsoe ho bona phello ea AAVC - Ⅰ ts'ebetsong ea ho falla ha lisele tsa endothelial;RT-PCR le blot ea Bophirimela li ne li sebelisetsoa ho lemoha liphetoho tsa mRNA le protheine ea P-selectin le intercellular adhesion factor (ICAM-1) pele le ka mor'a phekolo ea lithethefatsi.Liphello: Ha li bapisoa le HU VECs sehlopheng se tloaelehileng, bokhoni ba ho falla ha lisele tsa AAVC - Ⅰ lihlopha tsa mahloriso li fokotsehile ho ea ho tse fapaneng, 'me polelo ea P-selectin le ICAM-1 mRNA e fokotsehile haholo.Qetello: AAVC - Ⅰ e ka thibela ts'ebetso ea ho falla ha lisele tsa endothelial ka ho theola boemo ba mRNA le protheine ea P-selectin le ICAM-1.
Nako ea poso: Nov-29-2022