[Abstract] Sepheo: Ho ithuta phello ea Agkistrodon acutus venom tumor suppressor component I (AAVC-I) ka thibelo ea ho ata le apoptosis ea kankere ea matšoafo ea motho A549 lisele.Mekhoa: Litefiso tsa thibelo ea AAVC-I ka mekhahlelo e fapaneng ea lisele tsa A549 bakeng sa 24h le 48h li ne li lekantsoe ka mokhoa oa MTT;HE staining le Hoechst 33258 fluorescence staining li ile tsa sebelisoa ho hlokomela apoptosis ho tloha morphology;Polelo ea protheine ea bax e ile ea bonoa ke immunohistochemistry.Liphello: MTT e bontšitse hore AAVC-I e ka thibela ho ata ha lisele tsa A549 ka mokhoa o itšetlehileng ka nako le o itšetlehileng ka tekanyo;Ka mor'a phekolo ea AAVCI bakeng sa lihora tsa 24, nuclear pyknosis, nuclear hyperchromatic le apoptotic body li ile tsa hlokomeloa tlas'a microscope;Immunohistochemistry e bonts'itse hore karohano ea sekhahla sa mahlo e eketsehile ka keketseho ea khatello ea lithethefatsi, ho bonts'a hore polelo ea protheine ea bax e ne e laoloa ka tsela e tšoanang.Qetello: Antitumor component I ea Agkistrodon acutus venom e ka thibela mofetše oa matšoafo oa motho lisele tsa A549 le ho etsa hore apoptosis e be teng, e ka amanang le taolo e holimo ea polelo ea bax.
Nako ea poso: Jan-16-2023