Setsi sa Mahloko a Noha le Noha ea Loma, Koleche ea Bongaka ea Southern Anhui

Setsi sa Mahloko a Noha le Noha ea Loma, Koleche ea Bongaka ea Southern Anhui

Setsi sa Lipatlisiso sa Wuhu City, Profinseng ea Anhui

Lipatlisiso mabapi le mahloko a noha le leqeba la noha la Southern Anhui Medical College li qalile bohareng ba lilemo tsa bo-1970, 'me e ne e le setho sa Anhui Provincial Snake Wound Treatment Cooperation Group ka nako eo.Ke e 'ngoe ea litsi tsa pele tsa ho etsa lipatlisiso tsa mantlha le tse sebelisitsoeng mabapi le chefo ea noha Chaena.

Lebitso la Sechaena

Setsi sa Mahloko a Noha le Noha ea Loma, Koleche ea Bongaka ea Southern Anhui

sebaka

Profinseng ea Anhui

mofuta

sekolo sa lithuto tse phahameng

ntho

Chefo ea Noha le Leqeba la Noha

Liphihlello tsa lipatlisiso tsa Setsi

Selelekela ho Setsi

Lipatlisiso mabapi le mahloko a noha le leqeba la noha la Southern Anhui Medical College li qalile bohareng ba lilemo tsa bo-1970, 'me e ne e le setho sa Anhui Provincial Snake Wound Treatment Cooperation Group ka nako eo.Ka 1984, tlas'a boeta-pele ba Moprofesa Wen Shangwu, mookameli oa lefapha la thuto le lipatlisiso tsa baithuti ba pele ba kulang, ho ile ha thehoa Ofisi ea Lipatlisiso ea Chefo ea Snake le Snakebite, e leng e 'ngoe ea litsi tsa pele tsa ho etsa lipatlisiso tsa motheo le tse sebelisoang. ka chefo ea noha Chaena.Ka 2007, Ofisi ea Lipatlisiso ea Chefo ea Noha le Noha e ile ea rehoa Setsi sa Lipatlisiso sa Chefo ea Snake ea Southern Anhui Medical College, 'me mookameli oa hona joale ke Moprofesa Zhang Genbao.Lilemong tse 30 tse fetileng, likatleho tsa lipatlisiso tsa motheo le tse sebelisoang tsa chefo ea noha e chefo karolong e ka boroa ea Anhui li entse tlatsetso ea bohlokoa ho thibela le ho laola likotsi tsa noha le tšebeliso ea mehloli ea chefo ea noha Chaena;Linoha tse ka sehloohong tse chefo karolong e ka boroa ea Anhui ke Agkistrodon acutus (Agkistrodon acutus), Agkistrodon acutus, Cobra, Green Bamboo Leaf Snake, Chromium Iron Head le Bungarus multicinctus, haholo-holo Agkistrodon acutus, e amang bophelo bo botle le bophelo ba batho ba lithaba haholo.Liphuputso li bontšitse hore linoha tsena tse chefo haholo-holo li hlahisa chefo ea potoloho ea mali le li-neurotoxins, tse ka etsang hore bakuli ba hlokofatsoe ke ho phatlalatsoa ha intravascular coagulation (DIC) le mali a bobeli, ho tšoha, ho hlōleha ha litho tse ngata le liphello tse ling tse tebileng;Ka boithuto bo hlophisitsoeng mabapi le chefo ea mali ea chefo ea Agkistrodon acutus (Agkistrodon acutus) karolong e ka boroa ea Anhui, ho ile ha fumanoa hore DIC e amanang le ho loma ke noha e ne e le e 'ngoe ea matšoao a tlhaho a chefo ea pele,' me e ne e fapane le DIC e hlalositsoeng ka mokhoa oa setso. maikutlo.Ka hona, khopolo ea "DIC joaloka" syndrome ho bakuli ba longoang ke Agkistrodon acutus e ile ea hlahisoa ka lekhetlo la pele Chaena (1988), Hape ho ile ha hlokomeloa hore thrombin e kang enzyme (TLE) le fibrinolytic enzyme (FE) e leng chefo ea Agkistrodon acutus e ne e le teng. lisosa tse kholo tsa "DIC joalo ka" (1992).Sena se bohlokoa haholo ho hlakisa litšoaneleho tsa liphetoho tsa mali ho bakuli ba nang le Agkistrodon acutus, hape e fana ka motheo oa theory bakeng sa ts'ebeliso ea antivenine e itseng ho phekola bothata bona.Phuputsong e mabapi le mokhoa oa ho tsoa mali o bakoang ke chefo ea Agkistrodon acutus, ho ile ha boela ha fumanoa hore chefo ena ea noha e na le tšusumetso likarolong tse tharo tse kholo tsa tsamaiso ea mali (coagulation factor, platelets le marako a methapo ea mali), eo haemotoxin ka ho toba. e ama ho kenella ha li-capillaries.Ka nako e ts'oanang, ho ile ha lemohuoa hore ho tsoa mali ho tebileng ho bakoang ke chefo ea chefo ea Agkistrodon acutus le bothata ba ho ruruha ha maoto le matsoho a lemetseng ho fokotseha ho amana le ho thijoa ha lymphatic supplement ea coagulation factor in the thoracic duct le ho fokola ha lymphatic flow rate.Liphihlello tsena tsa motheo tsa lipatlisiso tsa motheo le tse sebelisoang li phethile karolo ea bohlokoa tšebelisanong ea nako e telele le Setsi sa Lipatlisiso sa Qimen Snakebite ho theheng ka nepo leano la kalafo bakeng sa ho longoa ke noha e chefo le ho netefatsa polokeho ea bakuli ba longoang ke noha, 'me ba fihletse liphello tse kholo sechabeng.Liphihlello tsa lipatlisiso li hapile ka tatellano Khau ea Katleho ea Saense le Thekenoloji ea Profinse ea Anhui, Khau ea Tsoelo-pele ea Saense le Thekenoloji ea Profinse ea Anhui (1993), le Khau ea (A) ea Phaello e Kopanetsoeng ea Saense le Thekenoloji ea Lekala la Bophelo bo Botle (1991);Ka 1989, e ile ea sebelisana le Wuhan Institute of Biological Products ho hlahisa antibody e le 'ngoe khahlanong le thrombin e kang enzyme ea Agkistrodon acutus venom, e leng katleho ea pele Chaena;Ka 1996, e kopanetse ho hlahisa le ho hlahisa lihlahisoa tsa thrombin (YWYZZ 1996 No. 118004, patent CN1141951A) le Institute of Biological Products le Lithethefatsi tsa Jinan Military Region.

liphuputso tsa lipatlisiso

Lilemong tsa morao tjena, laboratori e arotse le ho hloekisa mefuta e fapaneng ea lintho tse phelang le chefo e tala ea Agkistrodon acutus, Agkistrodon halys le Cobra e ka boroa ho Anhui, joalo ka li-anti hypercoagulable state enzymes, protein C activators (PCA).Liphuputso tsa liteko li netefalitse hore metsoako ena e sebetsang e ka ama ts'ebetso ea coagulation, ea ama platelet adhesion, aggregation le ho sireletsa ts'ebetso ea lisele tsa vascular endothelial, 'me li na le ts'ebetso e phahameng le e tlaase ea chefo ea anticoagulation le liphello tsa thrombolytic, Sena ke sa bohlokoa haholo bakeng sa thibelo le phekolo. mafu a thrombotic le ntlafatso ea hypercoagulability ea mali;Ka nako e ts'oanang, ho ile ha boela ha fumanoa hore PCA e tsoang mahlokong a noha e na le phello e tobileng ea ho bolaea lisele tsa leukemia tsa K562 le ho thibela metastasis ea lisele tsa kankere.Tebello ea ts'ebeliso ea eona ea tleliniki e pharaletseng haholo.Ofisi ea lipatlisiso e atlehile ho etsa le ho phethela merero e mengata ea lipatlisiso, joalo ka "Mechanism of DIC e bakoang ke Agkistrodon acutus venom", "Lipatlisiso mabapi le mokhoa oa ho tsoa mali o bakoang ke chefo ea Agkistrodon acutus liphoofolong", "Tlhahlobo ea ho longoa ke noha le ho fumanoa ha eona ka tsela e fapaneng. lelapa la noha ka mokhoa oa ho ngola li-enzyme ", e tšehelitsoeng ka lichelete ke National Natural Science Foundation, Lekala la Bophelo, Lefapha la Bophelo le Lefapha la Thuto la Profinse ea Anhui;Hona joale, merero e ntseng e tsoela pele e kenyelletsa: "Lipatlisiso ka Hemorrhagic Anticoagulant Protein ea Agkistrodon acutus", "Lipatlisiso ka Molecular Mechanism ea Effect ea PCA ho tloha Agkistrodon halys Pallas Venom ka Vascular Endothelial Function", "Research Biology ea Molek'hule. PCA e tsoang ho Agkistrodon acutus Venom khahlanong le Lisele Tsa Tumor ", le Karohano le Tlhoekiso ea Likarolo tsa Nerve Analgesic ho tloha Cobra Venom.

Setsi sa lipatlisiso tsa chefo ea noha sa South Anhui Medical College se na le maemo a matle a mantlha, lisebelisoa tse felletseng tsa ho etsa lipatlisiso, sebopeho sa sehlopha sa bafuputsi, le tsoelo-pele e tsoelang pele mekhoeng ea lipatlisiso le mekhoa ea tekheniki.Ho lebeletsoe ho etsa katleho e ncha lipatlisisong tsa saense, koetliso ea basebetsi, joalo-joalo Lisebelisoa tsa mahloko a noha karolong e ka boroa ea Anhui li ruile haholo ebile li bohlokoa.Snake venom pharmacy ke sethethefatsi se nang le litokelo tsa thepa ea mahlale naheng ea China.Liphetho tsa lipatlisiso motheong le tšebeliso ea chefo ea noha le likarolo tsa eona li bohlokoa haholo ho nts'etsopele ea lisebelisoa tse ruileng tsa mahloko a noha karolong e ka boroa ea Anhui le ts'ebeliso ea bongaka.