Haemocoagulase Acutus (Halase), thermostatic e ncha nts'etsopele ea halase, ke ts'ebetso e phahameng ea thrombobin joalo ka enzyme (TLE) e tsoang mahlokong a noha ea Agkistrodon acutus Ho ithuta pharmacokinetics ea Halase, mokhoa oa radioisotope o ngotsoeng ka 125Ⅰ le radioassay e kopantsoeng le radioassay. precip-itate e ne e sebelisoa ho likhoto.Liphetho li bontšitse hore boleng ba AUC bo ne bo amana hantle le litekanyetso tlas'a mekhoa e 'meli e sebelisitsoeng,' me coefficients ea khokahano e ne e le 0.999 8 le 0.999 0 ka ho latellana;Tšebeliso ea lithethefatsi sebeteng, spleen le pelo e fihlile tlhōrōng ea eona ka mor'a metsotso e 5 ea tsamaiso ha boholo ba li-or-gans tse ling li fihlile ho eona ka metsotso e 30, 'me butle-butle ea fokotseha;ka nako e 'ngoe le e' ngoe, khatello ea lithethefatsi sebeteng e ne e phahame haholo ho feta ea lisele tse ling;Halase e ile ea ntšoa ka ho feletseng 'me haholo-holo morong.Ke mofuta o mocha oa sethethefatsi sa hemostatic se entsoeng ke sehlopha sa rona Pharmacokinetics ea thrombin ho tloha Agkistrodon acutus ka likhoto e ile ea ithutoa ka mokhoa oa radioisotope oa 125 I-labeled le trichloroacetic acid precipitation hammoho le ho lemoha mahlaseli a kotsi.Liphello li bontšitse hore litekanyetso tsa AUC tse lekantsoeng ka mekhoa e 'meli li ne li amana hantle le tekanyo,' me li-coefficients tsa ho kopanya li ne li le 0.9998 le 0.9990, ka ho latellana;Lithethefatsi tse ka har'a sebete, spleen le pelo e ne e le metsotso e 5 e phahameng ka ho fetisisa ka mor'a tsamaiso, ha liphatsa tse ling tse ngata e ne e le tse phahameng ka ho fetisisa 30 min ka mor'a tsamaiso, ebe e fokotseha butle-butle;Ka nako e 'ngoe le e' ngoe, lihlahisoa tsa lithethefatsi ka har'a lisele tsa sebete li ne li phahame haholo ho feta tsa lisele tse ling;Ho feta moo, ho ntšoa ha thrombin ea Agkistrodon acutus ho phethehile, haholo-holo ka moroto.
Nako ea poso: Dec-08-2022