Chefo ea noha ke mokelikeli o ntšoang ke linoha tse chefo ho tsoa litšoeleseng tsa tsona tse chefo.Karolo ea eona e kholo ke protheine e chefo, e nkang 90% ho isa ho 95% ea boima bo omileng.Ho na le mefuta e ka bang 20 ea li-enzyme le chefo.Ntle le moo, e na le li-peptide tse nyane tsa limolek'hule, li-amino acid, lik'habohaedreite, lipids, nucleosides, li-amine tsa tlhaho le li-ion tsa tšepe.Sebopeho sa mahloko a noha se rarahane haholo, 'me chefo, pharmacology le liphello tsa toxicological tsa mefuta e sa tšoaneng ea linoha li na le litšobotsi tsa tsona.Har'a tsona, chefo e bontšoa ka tsela e latelang: 1. Chefo ea ho potoloha ha mali: (ho akarelletsa le chefo ea marabe, chefo ea agkistrodon acutus, chefo ea caltrodon, chefo ea noha e tala) 2. Li-neurotoxins: (chefo ea noha ea mahlo, chefo ea noha ea khauta, chefo ea noha ea silevera. , chefo ea noha ea morena, chefo ea noha) 3 Chefo e tsoakiloeng: (Agkistrodon halys venom, Ophiodon halys venom) ① Tšusumetso e thibelang mofetše ea chefo ea noha: mofetše ke le leng la mafu a mararo a maholo a behang bophelo ba batho kotsing, 'me ha ho na phekolo e sebetsang ho teng.Bo-rasaense ba tsoang linaheng tsohle ba nka thuto ea mahloko a noha e le sebaka se secha sa ho hlola mokoallo ona.Snake Venom Research Office of China Medical University e leka ho fumana metsoako e sebetsang e ka thibelang kholo ea hlahala ho tsoa ho chefo ea Agkistrodon halys e hlahisitsoeng Dalian, Liaoning, Teko e bapisang ea ho thibela tumor e entsoe lipakeng tsa chefo ea mantlha le chefo e ka thoko ea Agkistrodon halys Pallas. .Mefuta e robong e fapaneng ea chefo ea noha e na le likhato tse fapaneng tsa thibelo ho li-sarcomas tsa mouse, 'me sekhahla sa ho thibela hlahala se ka holimo ho 87.1%.② Tšusumetso ea anticoagulant ea chefo ea noha: "defibrase" e ntšitsoeng chefong ea Agkistrodon halys acutus e Yunnan, Chaena, e fetisitse boitsebiso ba tekheniki ka 1981, 'me e sebelisitsoe ho phekola linyeoe tse 333 tsa vascular thrombosis, ho akarelletsa le linyeoe tse 242 tsa cerebral thrombosis, sekhahla se sebetsang ke 86.4%.Agkistrodon halys antacid e entsoeng ke China Medical University le Shenyang Pharmaceutical College ka tšebelisano-'moho e fihletse liphello tse khotsofatsang tsa kliniki kalafong ea mafu a vascular occlusive.Antacid ea chefo ea noha e entsoeng ke Snake Venom Research Office of China Medical University e ka fokotsa lipids ea mali, ea atolosa methapo ea mali, ea fokotsa litaba tsa thromboxane maling, ea eketsa prostacyclin, le ho phomola mesifa e boreleli ea vascular.Ke ntho e ntle e khahlanong le.③ Ha e le phello ea hemostatic ea chefo ea noha, Japane e sebelisa motsoako oa coagulant o khothalletsang o boletsoeng ho marabe ho sebetsa ho opereishene ea bongaka, meriana ea ka hare, likarolo tsa sefahleho, mafu a basali le a pelehi le mafu a mang a tšollang mali.Moriana ona o bitsoa "ente ea reptilin".④ Tokiso ea serum ea antivenine: Nts'etsopele ea serum ea antivenine naheng ea China e qalile ka bo-1930.Ka mor'a tokoloho, Setsi sa Shanghai sa Lihlahisoa tsa Baeloji, ka tšebelisano-'moho le Sehlopha sa Lipatlisiso sa Snake sa Zhejiang Medical University, Setsi sa Zhejiang sa Traditional Chinese Medicine, le Guangzhou Medical College, se atlehile ho lokisa serum ea antivenine e hloekisitsoeng bakeng sa Agkistrodon halys, Agkistrodon acutus, Bungarus multicinctus, le Ophthalmus.⑤ Analgesic effect ea chefo ea noha: Ka 1976, Yunnan Kunming Animal Research Institute e atlehile ho hlahisa "Ketongling" ho tsoa mahlokong a mahloko a noha, e sebelisetsoang ho phekola maloetse a sa tšoaneng a bohloko 'me e fihletse phello e ikhethang ea analgesic."Motsoako oa Ketongning" o entsoeng ke Cao Yisheng o bontšitse katleho e ntle ea ho phekola bohloko ba methapo ea kutlo, bohloko ba kankere le detoxification.Hobane moriana o thethefatsang bohloko oa noha o na le tšebetso e phahameng ea ho kokobetsa bohloko 'me ha o lemalle, o sebelisoa ke bongaka ho nkela morphine sebaka sa ho alafa bohloko ba morao ba mofetše.Chefo ea chefo e ka sebelisoa ho lokisa serum e khethehileng ea anti-venom, analgesics le hemostatic agents.Phello ea eona e molemo ho feta morphine le dolantin, 'me ha e lemalle.Bohloko ba noha bo ka boela ba phekola lefu la ho shoa litho le pholio.Lilemong tsa morao tjena, chefo ea noha e 'nile ea sebelisoa ho phekola mofetše.Hobane chefo ea noha ke motsoako o entsoeng ka liprotheine tse 34, e 'ngoe ea tsona e le ea bohlokoa haholo' me palo e kholo ea chefo e bitsoa cytolysin.Ke chefo e senyang lisele le lisele tsa lisele ka ho khetheha.Sena se tla hlahisa lihlahala tse kotsi.Haeba cytolysin e tsoang mahlokong a noha e arohanngoa 'me e kenngoa' meleng oa motho ho hasana hohle 'meleng ka ho potoloha ha mali ho bolaea lisele tsa mofetše ka ho khetheha, ho na le tšepo e kholo ea ho hlōla bothata ba phekolo ea kankere.Defibrase bakeng sa ente e ntšoa chefong ea Agkistrodon acutus naheng ea China.E na le mosebetsi oa ho fokotsa fibrinogen le thrombolysis, 'me ke lithethefatsi tse khethehileng bakeng sa ho phekola mafu a pelo.Litšebeliso tse kholo tse robeli tsa chefo ea noha ke: 1. kalafo ea mofetše le anticancer, anti-tumor;2. Hemostasis le
Nako ea poso: Feb-11-2023